PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
October 11, 2025The OncologistOpen Access

62The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs

View Full Paper
Ask AI
Bookmark
Share

Authors

TGTreg GrubbPKPooneh KoochakiSMSayed Matar

Discussion

Loading...

Member takes

Overview

Study reveals SLC1A1's role in oncogenic metabolism in ccRCC, indicating H3K27ac dysregulation's impact.

Key Points

  • Loss of pVHL promotes HIF-independent expression of SLC1A1, critical for ccRCC growth.
  • Inactivation of SLC1A1 depletes essential metabolites, impeding ccRCC growth and enhancing drug sensitivity.
  • Higher SLC1A1 expression correlates with reduced immune infiltration and advanced metastatic disease in ccRCC.
  • Targeting SLC1A1 diminishes lung metastasis in animal models, supporting its therapeutic potential.

Cite This Study

Grubb et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1b5ba7d64b6fc131f15https://doi.org/10.1093/oncolo/oyaf276.063
View Full Paper
Ask AI
Bookmark
Share