What question did this study set out to answer?

This research aims to explore how SLC13A2 and its transported citrate influence tumor metabolism and transcriptional regulation in hepatocellular carcinoma.

April 10, 2026Science AdvancesOpen Access

SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth

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This research aims to explore how SLC13A2 and its transported citrate influence tumor metabolism and transcriptional regulation in hepatocellular carcinoma.
Integrated analysis of SLC transporters in liver tissues and cells
Conducted knockout and overexpression of SLC13A2 in mouse models
Performed flux analysis to study metabolic impacts of citrate transport
SLC13A2 down-regulation was consistent in HCC cells and tissues
SLC13A2 overexpression reduced HCC proliferation by affecting mitochondrial function
Citrate import from SLC13A2 enhanced acetyl-coenzyme A generation, leading to decreased pyruvate kinase activity
Increased protein acetylation provided an epigenetic basis for tumor suppression

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Implication

Demonstrates that SLC13A2 transport of citrate suppresses tumor growth in liver cancer, suggesting new therapeutic targets.

Cite This Study

Qin et al. (2026) studied this question.

synapsesocial.com/papers/69d896a46c1944d70ce0834f https://doi.org/10.1126/sciadv.aec4368

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SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth

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Discussion

Implication

Cite This Study

SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth

Key Points

Discussion

Implication

Cite This Study

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