Development of vismodegib-loaded PLGA nanoparticles for the treatment of pancreatic cancer: Formulation and in vitro assessment in co-culture monolayers and spheroids

Q: What type of study is this?

This is a Experimental Study study.

Ubah Abdi; M. Zhang; Wafa’ T. Al-Jamal

doi:10.1039/d5pm00161g

January 1, 2025RSC PharmaceuticsOpen Access

Development of vismodegib-loaded PLGA nanoparticles for the treatment of pancreatic cancer: Formulation and in vitro assessment in co-culture monolayers and spheroids

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Key Points

The formulation of vismodegib-loaded nanoparticles improved drug delivery in pancreatic cancer models.
In vitro assessments demonstrated effective treatment against pancreatic cancer in monolayers and spheroids.
Targeting the tumour microenvironment may enhance the efficacy of vismodegib in treating pancreatic cancer.
Co-culture techniques were vital in evaluating the nanoparticles' performance in mimicking the tumour microenvironment.

Implication

Formulation shows improved drug delivery in pancreatic cancer models, indicating enhanced efficacy.

Abstract

The desmoplastic tumour microenvironment (TME) is a defining feature of pancreatic cancer and presents as a major barrier to drug delivery and efficacy. Vismodegib is a clinically approved drug that...

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Cite This Study

Abdi et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1c1ba7d64b6fc1321a1 https://doi.org/10.1039/d5pm00161g

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Development of vismodegib-loaded PLGA nanoparticles for the treatment of pancreatic cancer: Formulation and in vitro assessment in co-culture monolayers and spheroids

Key Points

Implication

Abstract

Discussion

Cite This Study

Development of vismodegib-loaded PLGA nanoparticles for the treatment of pancreatic cancer: Formulation and in vitro assessment in co-culture monolayers and spheroids

Key Points

Implication

Abstract

Discussion

Cite This Study

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