The Antiaging Activity of Oil‐in‐Water Emulsions Prepared With Lycium barbarum Ethanol Extraction

Botanical extracts and cold‐pressed seed oils are increasingly recognized as potent antiaging actives and are being incorporated into functional food emulsions. Here, we developed an oil‐in‐water emulsions fortified with Lycium berries extract, a mixture rich in carotenoids and polyphenolic antioxidants. In vivo results revealed that the antiaging activity of the composite emulsion was significantly superior to that of the positive control group in skin protection. Histopathological assessment revealed a marked delay in epidermal thinning, enhanced dermal‐epidermal junction integrity, reduced wrinkle depth, and a 1.8‐fold increase in densely packed, well‐organized collagen bundles compared with the untreated group. Biochemical analysis of skin homogenates demonstrated robust antioxidant response: superoxide dismutase activity rose to 125.14 ± 6.51 U mg prot −1 , glutathione content reached 34.84 ± 1.35 U mg prot −1 , while malondialdehyde levels were suppressed to 5.48 ± 0.64 µg mL −1 . Collectively, these data indicate that Lycium barbarum extract‐based emulsions confer systemic cutaneous antiaging effects benefits and represent a promising nutraceutical strategy for functional foods aimed at mitigating aging.