This article discusses the need to replace animals in biomedical research, highlighting regulatory advancements and new methodologies to promote humane practices.
Real progress has been made towards replacing animals for risk assessment purposes, particularly given the recent announcement of comprehensive roadmaps by regulatory agencies. However, given the vast number of animals that continue to be used for biomedical purposes, perhaps now is the time to place greater emphasis on replacing animals in biomedical research. Scientific journals have a key role to play in encouraging the uptake of new approach methodologies and providing a supportive environment for a cultural shift to humane, sustainable Three Rs-based science.
No takes yet. Share an insight, caveat, or question.
Gilly Griffin (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: