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This is a Quantitative Study study.

October 11, 2025Frontiers in PhysicsOpen Access

Methodological benchmarking of GATE and TOPAS for 6 MV LINAC beam modeling and simulation efficiency

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Methodological comparison evaluates dosimetric accuracy and computational efficiency in GATE and TOPAS, indicating platform preference.

TOPAS showed superior agreement with experimental data in deep dose regions, highlighting its effectiveness for precise dose calculations.
Experimental validation was accomplished using percentage depth dose and dose profiles, ensuring reliability of simulation results.
GATE provided better computation times with advanced variance reduction techniques, making it suitable for time-sensitive applications.
Choosing the appropriate simulation platform is crucial for optimizing Monte Carlo simulations in clinical and research settings.

Elcadi et al. (2025) studied this question.

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