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October 11, 2025Open Access

Measuring appropriateness of antibiotic prescribing in high-income countries: a rapid systematic review of indicators

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Authors

RBRachel BerryNational Security AgencyLCLucy CatteauUniversity of MonsMCMartine G CarisLeiden University Medical Center

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Overview

Rapid systematic review identifies measures of antibiotic prescribing appropriateness, highlighting inappropriate use in high-income countries.

Key Points

  • The review identified 103 unique indicators for measuring appropriateness of antibiotic prescribing.
  • Among 165 studies, the compliance with guidelines was the most frequent general indicator, reported in 70% of studies.
  • Indicators showed inappropriate prescribing rates ranging from 2% to 88%, indicating a significant issue in antibiotic management.
  • Findings emphasize diverse settings and the complexity of measuring appropriate antibiotic use, supporting antimicrobial stewardship efforts.

Cite This Study

Berry et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1d0ba7d64b6fc132a8fhttps://doi.org/10.1101/2025.10.08.25337205
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  4. 4Global trends in inappropriate use of antibiotics, 2000–2021: scoping review and prevalence estimates2025
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