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October 11, 2025Open Access

Discrete protein dynamics enable long-range communication

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Authors

AKAlan KatzLSLevent SariLMLeigh J Manley

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Overview

Analysis shows how protein dynamics enhance allostery and long-range communication, indicating key properties in noisy environments.

Key Points

  • Focalized allostery enables proteins to communicate over long distances, with minimal structural changes affecting input and output sites.
  • Modeling shows that increasing the discreteness of internal degrees of freedom enhances allostery, mimicking properties found in real proteins.
  • The study utilizes a Variable-Well Dihedral model to examine interactions independent of chemical details and focuses on local interactions.
  • Results highlight that proteins can utilize digital-like signal processing to maintain communication efficiency in the presence of thermal noise.

Cite This Study

Katz et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1d0ba7d64b6fc132b46https://doi.org/10.1101/2025.10.08.681220
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