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October 11, 2025CellsOpen Access

Type 2 Diabetes Mellitus Impairs the Reverse Transendothelial Migration Capacity (rTEM) of Inflammatory CD14+CD16− Monocytes: Novel Mechanism for Enhanced Subendothelial Monocyte Accumulation in Diabetes

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Authors

DSDilvin SemoUniversity of MünsterASAdama SidibéUniversity of GenevaKSKallipatti Sanjith ShanmuganathanUniversity Hospital Münster

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Overview

Observational analysis reveals impaired rTEM in CD14+CD16− monocytes from T2DM patients, indicating enhanced inflammation and atherogenesis risk.

Key Points

  • Impaired reverse transendothelial migration (rTEM) significantly contributes to monocyte accumulation in T2DM individuals, promoting inflammation.
  • Monocytes from T2DM patients showed reduced chemotactic responses to CCL2 and CX3CL1, indicating dysfunction in monocyte migration.
  • Assessment using Boyden chamber assays and live-cell imaging revealed underwhelming transmigration of T2DM monocytes across endothelial cells.
  • These findings suggest that improving rTEM in T2DM monocytes could reduce their accumulation and inflammation in atherosclerosis.

Cite This Study

Semo et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1d0ba7d64b6fc132cc3https://doi.org/10.3390/cells14191567
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Also Consider

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  5. 5L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro2015 · 62 citations