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October 11, 2025The Journals of Gerontology Series AOpen Access

A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity

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Authors

MBMelkamu Bedimo BeyeneBasil Hetzel InstituteRVRenuka VisvanathanBasil Hetzel InstituteRARobel Alemu

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Implication

Genome-wide association study reveals 10 novel loci associated with intrinsic capacity, indicating genetic influences on well-being in older adults.

Key Points

  • The study found a significant genetic influence on intrinsic capacity, with a heritability estimate of 25.2% from the UK Biobank.
  • A genome-wide association study identified 38 independent SNPs across 10 genomic loci related to intrinsic capacity.
  • Post-GWAS analyses linked identified SNPs to important biological pathways, like metabolism and immune function.
  • Higher genetic loading for intrinsic capacity correlates with improved health outcomes in elderly individuals.

Cite This Study

Beyene et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1d9ba7d64b6fc132dc8https://doi.org/10.1093/gerona/glaf196
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