Meta-analysis reveals only slight increase in symptoms with antidepressant discontinuation, suggesting lower rates than previously thought.
A systematic review and meta‐analysis of 50 randomized controlled trials has found that although antidepressant discontinuation resulted in more symptoms than placebo discontinuation, the between‐group difference on average was only just over one symptom. The rate of antidepressant discontinuation symptoms was lower than that reported in earlier reviews. Results of the review and meta‐analysis were published online July 9, 2025, in JAMA Psychiatry .
No takes yet. Share an insight, caveat, or question.
A 2025 study studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: