Network meta-analysis compares deprescribing approaches, revealing benefits of slow tapering strategies for preventing relapse.
In what is believed to be the first network meta‐analysis that directly compares all of the main approaches to antidepressant deprescribing, slow tapering with psychological support was found comparably effective to antidepressant continuation in preventing depressive relapse. Rapid discontinuation strategies fared poorly in the analysis. Results of the meta‐analysis were published in the January 2026 issue of Lancet Psychiatry .
No takes yet. Share an insight, caveat, or question.
A 2026 study studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: