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October 11, 2025Saudi Pharmaceutical JournalOpen Access

Therapeutic potential of canagliflozin in DEN/TAA-induced renal cancer: mechanistic insights into NLRP3/IL-6/STAT3 and AMPK signaling and oxidative stress regulation

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Authors

RARehab F. Abdel‐RahmanMAMahdi H. AlsugoorNANaif Alsuhaymi

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Overview

Experimental analysis reveals canagliflozin reduced oxidative stress in renal cancer, highlighting potential therapeutic pathways.

Key Points

  • Canagliflozin reduced renal oxidative stress and enhanced antioxidant capacity in rats, suggesting protective effects.
  • Treatment with canagliflozin led to significant changes in histological indicators, supporting biochemical improvements.
  • Assessment involved inducing renal cancer in rats using diethyl nitrosamine and thioacetamide, with treatment starting from week 24.
  • Findings highlight the therapeutic potential of SGLT2 inhibitors like canagliflozin in combating renal cancer progression.

Cite This Study

Abdel‐Rahman et al. (2025) studied this question.

synapsesocial.com/papers/68ea72339f1bd4df558cec08https://doi.org/10.1007/s44446-025-00039-x
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