Research demonstrates that paxillin’s nuclear translocation influences gene splicing in neurons, suggesting a role in brain plasticity.
Paxillin, long known as a cytoplasmic scaffold protein involved in cell adhesion and migration, emerges in a new role as a nuclear regulator of alternative splicing in developing neurons. In this issue of The EMBO Journal, Chu and colleagues reveal that activity-dependent phosphorylation of paxillin at serine 119 promotes its nuclear translocation, enabling it to fine-tune gene splicing programs critical for synaptic refinement during sensitive periods of brain development.
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Sadhukhan et al. (2025) studied this question.
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