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October 12, 2025Annals of PIMS-Shaheed Zulfiqar Ali Bhutto Medical University

Expression of p53 as a Prognostic Marker in low and high-grade Urothelial Carcinoma: A Cross-Sectional Analysis

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Authors

IBIqra ButtHAHenna AzmatZTZainab Taj

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Overview

Cross-sectional analysis shows p53 correlates with tumor grade and invasion in urothelial carcinoma.

Key Points

  • High-grade tumors exhibited significantly higher p53 expression at both 10% and 40% cut-offs compared to low-grade tumors.
  • 84.6% of high-grade tumors were p53 positive at the 10% cut-off, while only 45.5% of low-grade tumors showed similar expression.
  • Aberrant p53 phenotypes were more frequent in high-grade tumors at 69.2%, indicating distinct differences between grades.
  • p53 positivity significantly correlated with lamina propria and muscularis propria invasion in urothelial carcinoma.

Cite This Study

Butt et al. (2024) studied this question.

synapsesocial.com/papers/68eb6f7ceea689731b300412https://doi.org/10.48036/apims.v20i4.743
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