New method synthesizes truxinate variants quickly and efficiently, highlighting base influence on formation.
Herein, we describe the synthesis of β‐truxinate via the [2 + 2] imerization of methyl 4‐nitrocinnamate and its base‐catalyzed isomerization by means of magnetic stirring activation using a liquid‐assisted strategy. With this methodology, it is also possible to obtain the corresponding ζ‐ and δ‐truxinates in short reaction times and with minimal solvent usage. Furthermore, it is possible to steer the process toward the preferential formation of ζ‐ or δ‐truxinate depending on the base being used.
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Bahena‐Martínez et al. (2025) studied this question.
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