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October 12, 2025Open Access

Varicella Zoster Virus Infection: Molecular Insights, Clinical Spectrum, and Advances in the Prevention and Management of Chickenpox and Shingles

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Varicella zoster virus can lead to debilitating postherpetic neuralgia, highlighting the impact of reactivation in older adults, especially those with compromised immunity.
Early initiation of antiviral therapy, such as acyclovir, can effectively reduce the severity of chickenpox and shingles, aiding faster recovery.
Vaccination with live-attenuated vaccines like Varivax® and Shingrix® significantly lowers the incidence of varicella and herpes zoster, demonstrating the importance of immunization.
Despite advancements in diagnostics like PCR, varicella zoster virus infection remains a significant public health concern, particularly in regions with low vaccine coverage.

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This review reveals the clinical spectrum of varicella and shingles, highlighting advances in antiviral therapy and vaccination strategies.

Iheukwumere et al. (2025) studied this question.

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This review reveals the clinical spectrum of varicella and shingles, highlighting advances in antiviral therapy and vaccination strategies.