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October 12, 2025Case Reports in DentistryOpen Access

Nonsurgical Retreatment of a 16 × 9 mm Osteolytic Lesion With Buccal Bone Regeneration Using a Bioceramic Sealer: A Clinical and NGS‐Based Microbiological Case Report With 30‐Month Follow‐Up

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Authors

ASAndrea SpinelliFDFrancesco d’ErricoABAlessio Buonavoglia

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Overview

Case report reveals complete resolution of osteolytic lesions in adult patient, indicating microbiological assessment's role in treatment planning.

Key Points

  • Complete resolution of a large osteolytic lesion was achieved following nonsurgical endodontic retreatment.
  • Next-generation sequencing revealed distinct bacterial profiles in the affected teeth, aiding treatment decision-making.
  • Combining manual, rotary, and reciprocating protocols with a bioceramic sealer effectively managed the extensive lesion.
  • Progressive healing was confirmed through radiographic assessments over a 30-month follow-up period.

Cite This Study

Spinelli et al. (2025) studied this question.

synapsesocial.com/papers/68ebabe3155248a327effc2ehttps://doi.org/10.1155/crid/9703223
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  1. 1Nonsurgical endodontic retreatment using a bioceramic sealer after apical surgery: a case series2026
  2. 2Nonsurgical Retreatment of a Failed Root Canal–Treated Mandibular First Molar Using a Bioceramic Sealer: Early Periapical Healing – A Case Report2026
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  4. 4Healing of a Large Periapical Lesion Using Non-Surgical Root Canal Retreatment: A Case Report2024 · 1 citations
  5. 5Radiographic Intraradicular Reduction of a Calcium Silicate–Based Sealer: Case Reports2026 · 1 citations