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October 12, 2025VirulenceOpen Access

Interaction with amoeba drives virulence-associated phenotypes in the Candida haemulonii complex

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Authors

AAArtid AmsriChiang Mai University KPKritsada PruksaphonWalailak University PTPatcharin ThammasitChiang Mai University

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Implication

Observational analysis reveals enhanced virulence and phenotypic changes in Candida haemulonii due to amoeba interaction, suggesting environmental influences on pathogenic traits.

Key Points

Amoeba interaction led to significant virulence and aggregation increases in Candida haemulonii variants.
Adapted isolates showed over 15-fold higher biofilm production compared to non-adapted controls while maintaining dimorphism.
Transcriptional analysis confirmed upregulation of key virulence and biofilm-related genes in amoeba-adapted strains.
Virulence assays demonstrated a significant reduction in lethal dose, indicating increased pathogenicity of amoeba-adapted isolates.

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Amsri et al. (2025) studied this question.

synapsesocial.com/papers/68ebabe3155248a327effcd0 https://doi.org/10.1080/21505594.2025.2570002

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Implication

Observational analysis reveals enhanced virulence and phenotypic changes in Candida haemulonii due to amoeba interaction, suggesting environmental influences on pathogenic traits.

Interaction with amoeba drives virulence-associated phenotypes in the Candida haemulonii complex

Discussion

Member takes

Implication

Key Points

Cite This Study

Interaction with amoeba drives virulence-associated phenotypes in the Candida haemulonii complex

Discussion

Member takes

Implication

Key Points

Cite This Study

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