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October 12, 2025Best Practice & Research Clinical RheumatologyOpen Access

Novel therapies for axial spondyloarthritis and future directions

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Authors

MDMarta DzhusWMWalter P. Maksymowych

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Overview

This update highlights novel targets and therapies in axial spondyloarthritis, indicating hope for better outcomes.

Key Points

  • Bimekizumab significantly improves clinical and imaging outcomes in axial spondyloarthritis.
  • Recent trials showed janus-kinase inhibitors with a favorable safety profile and lower uveitis rates.
  • Targets such as GM-CSF and MK2 were ineffective, but autoreactive T cell targeting shows promise.
  • Preclinical research on cytokines and kinases may lead to innovative therapies and improved patient care.

Cite This Study

Dzhus et al. (2025) studied this question.

synapsesocial.com/papers/68ebc91af2c3e4d8d926e239https://doi.org/10.1016/j.berh.2025.102105
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