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Targeting the BCL2 Family: Advances and Challenges in BH3 Mimetic-Based Therapies

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BH3 mimetics show promise in targeting the bcl2 family to promote apoptosis in cancer cells, yet face significant resistance challenges.
Clinical successes in hematologic malignancies demonstrate the potential of bh3 mimetics, but issues like toxicity remain concerning.
Developing combination therapies and immunomodulatory strategies may help overcome resistance mechanisms to bh3 mimetics.
Expanding therapeutic applications beyond oncology to autoimmune and fibrotic diseases highlights the versatility of bh3 mimetics.

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Review reveals significant clinical success of BH3 mimetics in cancer, highlighting challenges like resistance mechanisms and toxicity.

Mukherjee et al. (2025) studied this question.

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