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October 12, 2025DNAOpen Access

Genomic, Epigenomic, and Immuno-Genomic Regulations of Vitamin D Supplementation in Multiple Sclerosis: A Literature Review and in Silico Meta-Analysis

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Authors

PMP. ModakPBPritha BhattacharjeeKGKrishnendu Ghosh

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Overview

Literature review assesses genomic and epigenomic factors in MS, suggesting vitamin D's promise.

Key Points

  • Vitamin D supplementation shows potential to normalize oligodendrocyte activity and improve multiple sclerosis.
  • Evidence indicates that vitamin D deficiency relates to immune dysregulation, linked to aberrant genomic and epigenomic processes.
  • This systematic review analyzes transcriptome and methylome profiling, identifying significant genetic biomarkers for personalized therapy.
  • Integration of clinical evidence with in silico methods provides insights into therapeutic strategy using vitamin D in autoimmune disorders.

Cite This Study

Modak et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdac6ahttps://doi.org/10.3390/dna5040048
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1VITAMIN D3 IN THE PATHOGENESIS AND CLINICAL COURSE OF MULTIPLE SCLEROSIS: A COMPREHENSIVE REVIEW OF CURRENT EVIDENCE (2015–2026)2026
  2. 2The role of vitamin D in multiple sclerosis and its mechanisms of action2024
  3. 3Immunoregulatory effects and therapeutic potential of vitamin D in multiple sclerosis2020 · 27 citations
  4. 4Epigenetic and genetic insights for tailored therapeutic strategies in multiple sclerosis2026
  5. 5The immune cell transcriptome is modulated by vitamin D3 supplementation in people with a first demyelinating event participating in a randomized placebo-controlled trial2024 · 5 citations