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October 12, 2025Annals of Clinical and Experimental NeurologyOpen Access

Metabolic manifestations of Parkinson’s disease in cell models derived from induced pluripotent stem cells

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Authors

NKN. A. KolotyevaRMRegina S. MudarisovaNRN. A. Rozanova

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Overview

Review examines metabolic disturbances in Parkinson’s disease using iPSC models, highlighting diverse effects of SNCA mutations.

Key Points

  • The study reveals significant metabolic disturbances linked to specific SNCA gene mutations in neuronal cell models.
  • Cell models derived from induced pluripotent stem cells expose unique effects of SNCA mutations on cell function and metabolism.
  • Using iPSC-based models enables targeted investigations into Parkinson’s disease mechanisms by refining research objectives.
  • This approach supports the identification of new therapeutic targets and enhances diagnostic technologies for Parkinson’s disease.

Cite This Study

Kolotyeva et al. (2025) studied this question.

synapsesocial.com/papers/68ebe3d6becc64ad52fdadc6https://doi.org/10.17816/acen.1386
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