Acne vulgaris is a multifactorial inflammatory disorder of the pilosebaceous unit, primarily affecting adolescents and young adults. Synthetic anti-acne treatments, though effective, often cause irritation and antibiotic resistance. Consequently, herbal-based formulations are gaining popularity due to their safety and efficacy. Carica papaya (papaya) is a tropical fruit-bearing plant known for its remarkable dermatological and pharmacological properties. Its bioactive compounds—papain, chymopapain, flavonoids, alkaloids, and vitamins—exhibit antibacterial, antioxidant, keratolytic, and anti-inflammatory actions. This review emphasizes the pharmacognosy, phytochemistry, pharmacological activities, and potential of papaya in polyherbal anti-acne cream formulations
Shirsat et al. (Fri,) studied this question.