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October 12, 2025American Journal of NephrologyOpen Access

Upacicalcet Preserves Albumin Levels in Patients on Hemodialysis with Secondary Hyperparathyroidism: A Post-hoc Analysis of a Randomized Trial

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Authors

HKHirotaka KomabaSASeigo AkariYOYoshiyuki Ono

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Overview

Post-hoc analysis shows that upacicalcet stabilizes serum albumin levels in hemodialysis patients with secondary hyperparathyroidism, suggesting potential benefits for protein-energy wasting.

Key Points

  • Serum albumin levels remained stable in the upacicalcet group, compared to a decline in the placebo group.
  • Patients receiving upacicalcet showed a less steep slope in serum albumin change over time (0.09 g/dL per year).
  • Post-hoc analysis utilized mixed-effects models for repeated measures to compare serum albumin levels.
  • Further research is needed to explore long-term impacts of PTH control on protein-energy wasting.

Cite This Study

Komaba et al. (2025) studied this question.

synapsesocial.com/papers/68ebffcfdef9fcb308ff234ehttps://doi.org/10.1159/000548738
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