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October 12, 2025Reviews in Cardiovascular MedicineOpen Access

Antiplatelet Therapy in Chronic Coronary Artery Disease Patients With a History of Angioplasty. When is Aspirin Not Enough? A Systematic Review

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Authors

SFStylianos FiflisMPMichail PapamichalisΑXΑndrew Xanthopoulos

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Overview

Systematic review highlights antiplatelet therapy impact on thrombotic risks in coronary patients, suggesting individualized treatment strategies.

Key Points

  • Extended dual antiplatelet therapy showed improved outcomes compared to aspirin alone in coronary disease patients.
  • Long-term clopidogrel monotherapy was effective, yielding better primary outcomes and reducing major bleeding risks.
  • Subgroup analyses revealed significant benefits of extended therapy in those with prior myocardial infarction and peripheral artery disease.
  • Individualized treatments based on thrombotic and bleeding risks are crucial for optimal patient outcomes in coronary syndrome.

Cite This Study

Fiflis et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad050https://doi.org/10.31083/rcm44227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Is Aspirin Still Indispensable After PCI—Rethinking Dual Antiplatelet Therapy in Contemporary Practice2026
  2. 2Antiplatelet Monotherapies for Long-Term Secondary Prevention Following Percutaneous Coronary Intervention2025 · 7 citations
  3. 3Improving on current guidelines for aspirin-free strategies after percutaneous coronary intervention and future perspectives2025
  4. 4Optimal Long-term Antiplatelet Regimen for Patients with High Ischaemic and Bleeding Risks After Percutaneous Coronary Intervention2024 · 3 citations
  5. 5Optimal antiplatelet therapy for acute coronary syndrome patients with high risk for both ischemia and bleeding2024