Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 12, 2025Open Access

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states

View Full Paper
Ask AI
Bookmark
Share

Authors

RMRiley MullinsWashington University in St. LouisJZJesse M. ZaretskyWashington University in St. LouisESEmily StollerUniversity of Massachusetts Chan Medical School

Discussion

Loading...

Member takes

Implication

Analytical framework integrates TF binding and multi-omic sequencing in T cells, highlighting regulatory networks.

Key Points

  • Mapping transcription factors reveals their critical roles in human T cell memory and exhaustion states.
  • Using a novel platform, data demonstrated the unique behaviors of domain-swapped transcription factors on gene binding.
  • The adapted Calling Cards method enabled scalable transposon-based TF mapping for improved insights in primary human CD8 T cells.
  • Integration of TF binding with multi-omic data identified crucial gene programs and the dynamics of memory T cell enhancers.

Cite This Study

Mullins et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad187https://doi.org/10.1101/2025.10.09.681414
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters2012 · 39,907 citations
  2. 2TOX, through a glass, darkly2025 · 4 citations
  3. 3Moderated estimation of fold change and dispersion for RNA-seq data with DESeq22014 · 104,982 citations
  4. 4Visualizing transcription factor dynamics in living cells2018 · 214 citations
  5. 5CD34 Splice Variant: An Attractive Marker for Selection of Gene-Modified Cells2000 · 86 citations