Synthetic analysis reveals spiroacetal formation in γ-rubromycin using photochemical reaction of 2-hydroxy-1,4-naphthoquinone, indicating substrate tolerance varies with methoxy substituents.
The photochemical reaction of 2-hydroxy-1,4-naphthoquinone gives [5,6]-spiroacetal structure, a partial structure in γ-rubromycin. The viability of the reaction depended on the number of methoxy substituents on the naphthoquinone moiety, and the substrate tolerance has been studied.
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Ando et al. (2025) studied this question.
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