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Short Overview on the Involvement of Lipid Peroxidation Product 4-Hydroxynonenal in Diverse Pathways of Cell Death

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4-hydroxynonenal's involvement in cell death includes apoptosis, necrosis, and ferroptosis, revealing its diverse roles.
Research on 4-HNE shows various pathways of cell death, including programmed cell death and necroptosis, emphasizing its importance.
Oxidative stress generates 4-HNE, acting not only as a cytotoxic mediator but also as a signaling molecule in various diseases.
The findings encourage future research into using 4-HNE as a therapeutic target in the treatment of cancer and degenerative diseases.

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This review highlights the involvement of 4-hydroxynonenal in various cell death mechanisms, suggesting its potential in cancer therapies.

Jaganjac et al. (2025) studied this question.

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This review highlights the involvement of 4-hydroxynonenal in various cell death mechanisms, suggesting its potential in cancer therapies.