Retrospective study shows that metagenomic next-generation sequencing enhances diagnostic accuracy for HIV coinfections, suggesting it as a valuable tool.
Key Points
Metagenomic next-generation sequencing demonstrated a higher detection rate for coinfections than conventional tests.
In this study, mNGS achieved a sensitivity of 80% and specificity of 75%, compared to 20% and 100% for CMT.
Combining CMT with mNGS improved the diagnostic sensitivity to 86.67%, indicating enhanced accuracy.
Treatment adjustments in HIV patients treated based on mNGS results led to more effective outcomes compared to CMT alone.