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October 13, 2025Archive of Ukrainian OphthalmologyOpen Access

Changes in the endothelial functional state on the background of diabetic retinopathy (experimental modelling)

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Authors

ODO.Yu. Denysiuk

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Overview

Experimental modeling shows changes in endothelial dysfunction in diabetic retinopathy, suggesting serious impacts on microvascular health.

Key Points

  • Endothelial dysfunction was marked by increases in endothelin-1 and VCAM, alongside a decrease in t-PA levels.
  • Significant changes in endothelial function were evident from day 60 in a rat model of type 2 diabetes.
  • A streptozotocin-induced model demonstrated critical insights into the pathogenesis of diabetes complications.
  • The findings highlight the endothelial state's importance in predicting diabetic retinopathy outcomes.

Cite This Study

O.Yu. Denysiuk (2025) studied this question.

synapsesocial.com/papers/68ec51df42911f61ef8b218ehttps://doi.org/10.22141/2309-8147.13.2.2025.412
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