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October 13, 2025Annals of MedicineOpen Access

The efficacy and safety of doravirine/lamivudine/tenofovir disoproxil fumarate in treatment-naïve and treatment-experienced patients with HIV

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Authors

HYHonghong YangMLMei LiQLQian Liu

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Overview

Observational analysis shows good efficacy and safety of doravirine/lamivudine/tenofovir in HIV patients, indicating potential for broader use in treatment-experienced cases.

Key Points

  • Doravirine-based treatment shows promising efficacy in both treatment-naïve and treatment-experienced HIV patients, enhancing therapeutic options.
  • Real-world evidence highlights safety and tolerability of doravirine/lamivudine/tenofovir fumarate for HIV, crucial for treatment strategies in diverse populations.
  • The study suggests further exploration of doravirine's effectiveness can inform treatment guidelines, improving health outcomes for HIV patients globally.
  • Findings advocate for the inclusion of doravirine in HIV treatment protocols, particularly in regions with limited existing data.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68ec51df42911f61ef8b22a2https://doi.org/10.1080/07853890.2025.2564286
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term effectiveness, safety, and tolerability of doravirine in antiretroviral-experienced people with HIV in real life2024 · 6 citations
  2. 2DORAVIR: a French national survey of people with HIV-1 treated with an antiretroviral regimen including doravirine2024 · 3 citations
  3. 3Long‑Term Effectiveness and Safety of Doravirine‑Based Antiretroviral Regimens in Virologically Suppressed People with HIV: The French Dat’AIDS Cohort2026
  4. 4Efficacy and safety of doravirine/lamivudine/tenofovir as initial treatment for people living with HIV in China2026
  5. 5Profile of People Living with HIV Switching Prior Antiretroviral Treatment to a Doravirine-Based Regimen in the Real-World Clinical Setting in Greece: The Retrospective DORAVITO Study2026