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October 13, 2025Open Access

Effects of dipicolinic acid on Bacillus anthracis spore biology and cytotoxicity

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Authors

CHChandler Hassan-CasarezUniversity of Nevada, Las VegasTMTiffany V. MataUniversity of Nevada, Las VegasEAErnesto Abel‐SantosUniversity of Nevada, Las Vegas

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Implication

Experimental analysis reveals distinct effects of dipicolinic acid on spore biology and cytotoxicity in Bacillus anthracis.

Key Points

  • DPA is essential for normal spore biology but does not affect macrophage-targeted virulence.
  • Single- and double-mutant DPA-less spores showed compromised dormancy and germination rates.
  • Each DPA synthesis mutant displayed unique viability and heat resistance phenotypes.
  • SpoVV transporter and SleB protein redundancy indicate complex roles in spore cytotoxicity.

Cite This Study

Hassan-Casarez et al. (2025) studied this question.

synapsesocial.com/papers/68ecc715d1cc7436f7d18aaehttps://doi.org/10.1101/2025.10.10.681759
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