Nano Aloe Vera Based Chitosan Delivery Systems in Dentistry: Therapeutic Potentials and Biomedical Advancements

Aloe vera is a well-documented medicinal plant known for its potent anti-inflammatory, antimicrobial, antioxidant, and wound-healing properties. However, its direct application in dental therapeutics is limited due to poor stability and bioavailability. The advancement of nanotechnology has enabled the development of Aloe vera-loaded chitosan nanoparticles, which offer enhanced mucoadhesion, controlled drug release, and targeted delivery to oral tissues. This review explores the therapeutic potential of nano Aloe vera chitosan systems in the context of dental applications, including periodontitis, oral ulcers, caries prevention, and post-surgical healing. The mechanisms of action, such as mucoadhesion, antimicrobial synergy, sustained release, and immune modulation, are critically discussed. Furthermore, the review highlights relevant preclinical and clinical findings, challenges in standardization and regulatory pathways, and emerging directions like stimuli responsive delivery and integration with regenerative materials. The convergence of phytotherapy and nanotechnology presents a promising frontier for biocompatible and effective oral healthcare interventions.