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This is a Literature Review study.

October 13, 2025

[The mechanism of mitochondrial damage in chronic obstructive pulmonary disease induced by cigarette smoke and its therapeutic implications].

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This review highlights how cigarette smoke induces mitochondrial dysfunction in COPD, suggesting mitochondrial targets may mitigate oxidative damage.

Mitochondrial dysfunction in COPD contributes to persistent inflammatory responses and increased cell apoptosis, creating a damaging cycle.
Cigarette smoke induces oxidative stress by impairing mitochondrial DNA and function, ultimately reducing ATP production.
Dysregulated mitochondrial dynamics, including fusion and fission imbalances, is vital in worsening COPD pathology and inflammation.
Targeting mitochondrial dysfunction is a promising therapeutic strategy for preventing and treating chronic obstructive pulmonary disease.

Zhao et al. (2025) studied this question.

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This review highlights how cigarette smoke induces mitochondrial dysfunction in COPD, suggesting mitochondrial targets may mitigate oxidative damage.