Entropic active particle transport in pulsating 3D geometries

We study the transport of active Brownian particles (ABPs) in three-dimensional (3D) oscillatory geometries, which are spatially periodic. We establish a generalized Fick-Jacobs approach, which reduces a 3D system to an effective 1D system based on the assumption that a fast equilibration of particles along the transversal directions of the geometry. The transport characteristics of ABPs are computed semi-analytically and corroborated by numerical simulations. At the optimal frequency of the geometry oscillation, particles exhibit higher average velocity v and effective diffusion coefficient Deff, resembling the phenomena of stochastic resonance. This effect is further enhanced by the self-propelled velocity of ABPs and the amplitude of geometry oscillations. These findings have significant implications for the development of micro- and nanofluidic devices with enhanced control over particle transport and precise manipulation of small-scale biomedical devices.