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This is a Quantitative Study study (also classified as: Experimental Study).

October 13, 2025Open Access

Modes of Mechanical Guidance of Adhesion-Independent Cell Migration

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Active surface dynamics generate stimulus-specific cell behaviors, enhancing migration up friction gradients.
The phase-field model accommodates large shape deformations and includes a diffusible contraction-generating molecule, myosin.
Mechanics of active surfaces illuminate processes beyond cell migration, providing insights into biological system functions.
Cortical activity induces spontaneous symmetry breaking, leading to persistent migration patterns in narrow environments.

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Phase-field model demonstrates directed cell motility in confined spaces, suggesting mechanical cues impact cell behaviors.

Gertack et al. (2025) studied this question.

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