Experimental study demonstrates enhanced tissue healing with parietal peritoneal patch versus primary suturing in canines, suggesting a viable surgical alternative.
Abstract Intestinal perforation is a surgical emergency associated with a significant morbidity and mortality. Current repair techniques such as primary suturing may be inefficient. The aim of this study was to evaluate the efficacy of autologous parietal peritoneal patch for the repair of small intestinal perforations. Twelve dogs were randomly assigned to two groups: Group A (n = 6) underwent repair using a parietal peritoneal patch, while Group B (n = 6) received conventional primary suturing. Animals were monitored clinically for 8 weeks. At endpoint, macroscopic and histological outcomes were assessed. All 12 dogs survived without major complications. The peritoneal patch group showed organized healing with neomucosal regeneration, minimal adhesions, and no stricture formation. In contrast, the control group showed more extensive adhesions, fibrosis, and stricture formation. Histological examination confirmed mature granulation tissue and epithelial coverage in Group A. Autologous parietal peritoneal patch offers a promising, biologically compatible technique for intestinal perforation repair. Compared to primary suturing, this approach reduced adhesions and enhanced tissue healing. Further studies are needed to validate its potential in gastrointestinal surgery.
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Mabrouk et al. (2025) studied this question.
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