October 13, 2025Open Access

Hepatoprotective Effects of Vernonia amygdalina Leaf Extract: In Vivo and In Silico Evidence Against Ethanol-Induced Liver Injury

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In vivo study shows Vernonia amygdalina improves liver function in rats exposed to ethanol, highlighting active compounds via network pharmacology.

Vernonia amygdalina extract significantly reduces liver damage caused by ethanol, improving liver function markers.
At 300 mg/kg, the extract decreased SGPT from 110.31 to 88.65 U/mL and total bilirubin from 1.19 to 0.59 g/dL.
Active compounds identified through network pharmacology include flavonoids and sesquiterpene lactones targeting ALD-related proteins.
Molecular docking studies reveal strong binding affinities of key compounds with liver proteins, indicating therapeutic potential.

Fosu et al. (2025) studied this question.

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In vivo study shows Vernonia amygdalina improves liver function in rats exposed to ethanol, highlighting active compounds via network pharmacology.