Observational analysis reveals mutable data classes in CDK require change notifications, indicating importance of updating dependencies.
The data classes of the Chemistry Development Kit are mutable, unlike those of Octet. This means that other classes may need to respond when the content updates. For example, a render class. CDK's ChemObject provides a notifyChanged() and addListener() methods for this.
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Egon Willighagen (2006) studied this question.