Case presents acute muscle weakness due to hypokalaemia in a 17-year-old, highlighting risks of HPP.
Hypokalaemic periodic paralysis (HPP) is a rare neuromuscular disorder characterized by recurrent episodes of transient muscle weakness associated with hypokalaemia. The condition typically presents in childhood or adolescence. In this case, a 17-year-old male presented with acute-onset limb weakness upon waking. Examination revealed marked truncal and proximal muscle weakness with preserved distal strength. Serum potassium was 2.7 mmol/L. His symptoms fully resolved following intravenous potassium replacement. HPP is often underdiagnosed, and diagnostic delays can leave patients vulnerable to avoidable complications, including recurrent episodes and potentially life-threatening arrhythmias. This case highlights the importance of considering HPP in young patients presenting with acute muscle weakness and hypokalaemia.
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Wani et al. (2025) studied this question.
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