Association between Cumulative Fluid Overload and Clinical Outcomes in Intensive Care Unit Patients with Sepsis: A Retrospective Cohort Study

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Retrospective cohort study finds fluid overload significantly linked to higher mortality and organ dysfunction in patients with sepsis.

Fluid overload is an independent predictor of higher mortality in ICU patients, indicating critical importance of proper fluid management.
Patients with fluid overload experienced a drastically higher cumulative fluid balance, averaging -724.5 mL for non-survivors versus -1924 mL for survivors.
The study used multivariable regression analyses to assess the impact of cumulative fluid balance on mortality and identified key predictors.
These findings emphasize the necessity for personalized fluid management strategies in sepsis treatment to mitigate risks of mortality.

Zulkifili et al. (2025) studied this question.

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View Full Paper

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Authors

Retrospective cohort study finds fluid overload significantly linked to higher mortality and organ dysfunction in patients with sepsis.

Fluid overload is an independent predictor of higher mortality in ICU patients, indicating critical importance of proper fluid management.
Patients with fluid overload experienced a drastically higher cumulative fluid balance, averaging -724.5 mL for non-survivors versus -1924 mL for survivors.
The study used multivariable regression analyses to assess the impact of cumulative fluid balance on mortality and identified key predictors.
These findings emphasize the necessity for personalized fluid management strategies in sepsis treatment to mitigate risks of mortality.

Zulkifili et al. (2025) studied this question.

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