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October 15, 2025Acta Neuropathologica CommunicationsOpen Access

Ablation of progranulin augments microglial activation and accelerates prion progression

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Authors

BLBei LiYSYixin ShiWHWenyu Hou

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Overview

This study shows that the loss of progranulin enhances microglial activation in prion diseases, indicating its neuroprotective role.

Key Points

  • Ablation of progranulin leads to accelerated disease progression in prion-infected mice, demonstrating its critical neuroprotective role.
  • Histological analysis reveals augmented microglial activation and exacerbated astrogliosis in mice lacking progranulin.
  • RNA-seq analysis shows that progranulin deficiency shifts microglia to a pro-inflammatory state, influencing prion progression.
  • Findings suggest that targeting progranulin expression could represent a new therapeutic strategy for prion diseases.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68efbd16d61273c8652d7f03https://doi.org/10.1186/s40478-025-02128-3
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