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October 15, 2025Molecular Biology and EvolutionOpen Access

Organism-Specific Sequence Motifs Link Ribosomal RNAs to Brain Disorders

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Authors

IRIsidore RigoutsosSNStepan NersisyanELEric Londin

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Overview

Observational analysis identifies sequence motifs in ribosomal RNAs linked to brain disorders, suggesting a regulatory role in nervous system genes.

Key Points

  • Specific combinations of ribosomal RNA motifs are found in 1,046 human genes linked to brain disorders, including autism and schizophrenia.
  • The study reports 1,723 organism-specific sequence motifs in ribosomal RNAs, predominantly associated with nervous system genes.
  • Analysis of brain sample expression shows motifs enriched in genes downregulated in autism spectrum disorder patients, particularly in areas related to language.
  • These discoveries highlight a regulatory layer influencing brain disorders, with potential implications for molecular diagnostics.

Cite This Study

Rigoutsos et al. (2025) studied this question.

synapsesocial.com/papers/68efbd16d61273c8652d81c9https://doi.org/10.1093/molbev/msaf237
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain2024 · 4 citations
  2. 2So Fragile, So Human: Noncoding DNA Regions Orchestrating Gene Expression Involved in Neurodevelopmental Disorders and in Human Brain Evolution2026
  3. 3Brain Extracellular Matrix implications in multiple neurological disorders are revealed through a meta-analysis of transcriptional changes2024 · 1 citations
  4. 4Beyond the gene: isoform diversity as a key contributor to human brain disorders2026
  5. 5<i>In silico</i> Mapping of Non-Canonical DNA Structures Across the Human Ribosomal DNA Locus2025