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December 10, 2025G3 Genes Genomes GeneticsOpen Access

In silico Mapping of Non-Canonical DNA Structures Across the Human Ribosomal DNA Locus

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Authors

JAJyoti D AdalaBKBruce A. Knutson

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Overview

In silico mapping identifies G4s and regulatory features in ribosomal DNA, suggesting pathways for therapeutic intervention.

Key Points

  • To create a comprehensive map of non-canonical DNA structures across the human ribosomal DNA locus.
  • Used computational tools to identify predicted non-canonical structures (PNCSS) in human rDNA.
  • Analyzed distribution of R-loops, G-quadruplexes, and i-motifs in various rDNA regions.
  • Examined correlation between PNCSS locations and RNA polymerase I occupancy.
  • Identified specific regions enriched in PNCSS, including spacer and coding regions.
  • Found strong strand asymmetry and co-localization of motifs.
  • Noted inverse correlation between PNCSS and RNA polymerase I occupancy.

Cite This Study

Adala et al. (2025) studied this question.

synapsesocial.com/papers/69401d472d562116f28f86f4https://doi.org/10.1093/g3journal/jkaf299
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