Research reveals high-fructose diet causes metabolic alterations and OAB-like symptoms in juvenile rats, suggesting potential therapy avenues.
Key Points
High-fructose intake induces significant metabolic and functional changes in juvenile rats, increasing urination frequency and impairing bladder function.
The model group exhibited disrupted body weight and lipid metabolism, with heightened oxidative stress and altered energy metabolism patterns.
Assessment included Western blot analysis and metabolomic profiling to confirm activation of the CaMKK2/AMPK signaling pathway in bladder tissue.
Findings highlight the link between fructose metabolism and bladder dysfunction, indicating the need for further exploration of antioxidant strategies.