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October 15, 2025Frontiers in GeneticsOpen Access

Transcriptomic profiling reveals macrophage gene signatures associated with lactylation-related pathways in chronic obstructive pulmonary disease

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Authors

HGHui GuoWSWeilin SunFZFang‐Jie Zhao

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Overview

Observational analysis discovered novel macrophage biomarkers in chronic obstructive pulmonary disease, suggesting roles in immune dysregulation.

Key Points

  • Three key biomarkers were identified, potentially enabling targeted therapies for chronic obstructive pulmonary disease.
  • The nomogram model accurately predicted patient mortality, indicating the clinical relevance of the biomarkers.
  • Weighted gene co-expression network analysis revealed associations with metabolic pathways and B-cell receptor signaling.
  • In vitro experiments validated the findings, suggesting strong clinical implications for therapeutic strategies.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68efd921056559ef4287754fhttps://doi.org/10.3389/fgene.2025.1653163
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