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October 15, 2025Cognizance Journal of Multidisciplinary Studies

Sulfonamide Derivatives as Potent VEGFR-2 Inhibitors: Advances and Therapeutic Perspectives: A Comprehensive Review

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Authors

ARAli Jabbar RadhiYYYahiya Ibrahim YahiyaHAHasanain A.H. Al-Hadrawi

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Overview

Comprehensive review reveals sulfonamide derivatives' role in VEGFR-2 inhibition, suggesting advances in drug design and nanotechnology.

Key Points

  • Sulfonamide derivatives are highlighted as potent VEGFR-2 inhibitors for anticancer therapy, showcasing their versatility.
  • The review details structural requirements and binding modes, emphasizing their pharmacological significance in rational drug design.
  • Advanced computational methods, including QSAR modeling, are noted to enhance the efficiency of drug development strategies.
  • Nanotechnology applications are discussed for improving drug delivery, pointing to enhanced solubility and site-specific release mechanisms.

Cite This Study

Radhi et al. (2025) studied this question.

synapsesocial.com/papers/68eff7392ae617e5891a94bdhttps://doi.org/10.47760/cognizance.2025.v05i10.012
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