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Isolated Positive Treponemal Test in Pregnancy and Placental Abnormalities Without Confirmed Syphilis Infection: A Case Report

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Case report reveals challenges of interpreting treponemal tests in pregnancy, indicating potential congenital syphilis risk.

Isolated positive treponemal tests can complicate syphilis diagnosis in pregnancy, raising concerns over congenital syphilis.
Placental examination revealed multiple intervillous abscesses and chronic villitis, suggestive of congenital syphilis complications.
Lack of confirmed maternal infection necessitated full evaluation for neonatal congenital syphilis, highlighting important healthcare considerations.
This case emphasizes the need for standardized management algorithms to prevent misclassification and overtreatment.

Stiles et al. (2025) studied this question.

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