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This study demonstrates the antiparasitic potential of peptoids against Cryptosporidium parvum, suggesting new therapeutic options.
Cryptosporidiosis, caused by Cryptosporidium parvum , poses significant health risks, particularly for children and immunocompromised individuals. Current treatments are ineffective in these vulnerable groups. This study explores the antiparasitic effects of peptoids against C. parvum . Out of 14 synthetic peptidomimetics (peptoids) screened, TM9 and TM19 exhibited potent anti-cryptosporidial activity with minimal host toxicity. These findings suggest that peptoids could be a promising new therapeutic avenue for cryptosporidiosis, warranting further investigation.
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Lamont et al. (2025) studied this question.
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